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function StringReplace (const S, OldPattern, NewPattern: string; Flags: TReplaceFlags): string;

rfReplaceAll:全部替换
rfIgnoreCase:忽略大小写

For Example:

var
    aStr: String;
begin
    aStr := 'This is a book, not a pen!';
    ShowMessage(StringReplace (aStr, 'a', 'two', []));//This is two book, not a pen!只替换了第一个符合的字
    ShowMessage(StringReplace (aStr, 'a', 'two', [rfReplaceAll]));//This is two book, not two pen!替换了所有符合的字
    aStr := 'This is a book, not A pen!';
    ShowMessage(StringReplace (aStr, 'a', 'two', [rfReplaceAll]));//This is two book, not A pen!只替换了符合的字(小写a)
    ShowMessage(StringReplace (aStr, 'a', 'two', [rfReplaceAll, rfIgnoreCase]));//This is two book, not two pen!不管大小写替换了所有符合的字
end;